Sex Differences in Risk of Lung Cancer Associated with Methylene-tetrahydrofolate Reductase Polymorphisms
نویسندگان
چکیده
منابع مشابه
Sex differences in risk of lung cancer associated with methylene-tetrahydrofolate reductase polymorphisms.
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Variations in MTHFR functions likely play roles in the etiology of lung cancer. The MTHFR gene has three nonsynonymous single nucleotide polymorphisms (i.e., C677T, A1298C, and G1793A) that have a minor allele frequency of >5%. We investigated the associations betw...
متن کاملShort Communication Polymorphisms of Methylene-tetrahydrofolate Reductase and Risk of Lung Cancer: A Case-Control Study
Previous studies have suggested that low folate intake is associated with increased risk of lung cancer. Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and is thought to influence DNA methylation and nucleotide synthesis. MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level...
متن کاملPolymorphisms of methylene-tetrahydrofolate reductase and risk of lung cancer: a case-control study.
Previous studies have suggested that low folate intake is associated with increased risk of lung cancer. Methylene-tetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and is thought to influence DNA methylation and nucleotide synthesis. MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate leve...
متن کاملA single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy.
BACKGROUND This study examined the association between functional single-nucleotide polymorphisms in candidate genes from oxidative stress pathways and risk of radiation pneumonitis (RP) in patients treated with thoracic radiation therapy for locally advanced lung cancer. METHODS A review was conducted of 136 patients treated with radiation therapy for lung cancer between 2001 and 2007, and w...
متن کاملPolymorphisms in the methylene tetrahydrofolate reductase and methionine synthase reductase genes and their correlation with unexplained recurrent spontaneous abortion susceptibility.
We aimed to explore the correlation between unexplained recurrent spontaneous abortion and polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes. A case control study was conducted in 118 patients with unexplained recurrent spontaneous abortion (abortion group) and 174 healthy women (control group). The genetic material was extracted fr...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2005
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-04-0905